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Precision forging technology for aluminum alloy

Lei DENG, Xinyun WANG, Junsong JIN, Juchen XIA

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1, Pages 25-36 doi: 10.1007/s11465-018-0477-y

Abstract: In this paper, progresses in precision forging technologies of aluminum alloy parts were reviewed.Several advanced precision forging technologies have been developed, including closed die forging, isothermaldie forging, local loading forging, metal flow forging with relief cavity, auxiliary force or vibrationHigh-precision aluminum alloy parts can be realized by controlling the forging processes and parametersor combining precision forging technologies with other forming technologies.

Keywords： precision forging aluminum alloy closed die forging flow control forging hybrid-forming technology

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The Near β Forging Overthrows the Conventional Forging Theory and Develops a New Tri-modal Microstructure

Zhou Yigang,Zeng Weidong,Yu Hanqing

Strategic Study of CAE 2001, Volume 3, Issue 5, Pages 61-66

Abstract:

The near beta forging for titanium alloys proposed by the authors has overthrown the conventionalforging theory in the following two aspects: firstly, the material is heated and forged at 10〜15℃ belowbeta transus temperature and then water cooled; secondly, the heat treatment technology after forgingtransformation, defomation and strengthening and toughening theory, materials forged by the near beta forgingThe near beta forging is applicable not only to alpha-beta alloy, but also to alpha, near alpha and near

Keywords： titanium alloy near beta forging tri-modal microstructure

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Do not let precision medicine be kidnapped

Zhiping Yang

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 512-513 doi: 10.1007/s11684-015-0425-8

Abstract:

Obama’s precision medicine initiative made the medical community boil over after the initiativePrecision medicine has been advocated by the majority of scientists and doctors.This article does not oppose precision medicine.However, the incentive of vigorously promoting precision medicine at present is a concern.

Keywords： precision medicine personalized medicine genomics

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2, Pages 158-180 doi: 10.1007/s11465-017-0455-9

Abstract:

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracyThe conception, applications and history of ultra-precision machining are introduced in this article,and the developments of ultra-precision machining technologies, especially ultra-precision grinding,ultra-precision cutting and polishing are also reviewed.

Keywords： ultra-precision grinding ultra-precision cutting ultra-precision polishing research status in China development

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Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3, Pages 348-353 doi: 10.1007/s11465-008-0065-7

Abstract: This paper presents the principle of self-generation of machining precision by explaining its basic conceptThe self-generation of machining precision for solid balls with super precision is emphatically explainedNecessary conditions for achieving self-generation of machining precision are given.Establishment of the system for machining solid balls with super precision is discussed.Self-generation of machining precision for solid balls with super precision on the basis of the capability

Keywords： self-generation necessary self-regulation capability viewpoint Necessary

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Human pangenome: far-reaching implications in precision medicine

Frontiers of Medicine doi: 10.1007/s11684-023-1039-1

Abstract: Human pangenome: far-reaching implications in precision medicine

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Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 391-392 doi: 10.15302/J-FASE-2018246

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High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 393-405 doi: 10.15302/J-FASE-2018226

Abstract:

The central concept of precision agriculture is to manage within-field soil and crop growth variabilityRemote sensing has been an integral part of precision agriculture since the farming technology startedagricultural applications over large geographic areas since the 1970s, but they have limited use for precisionaerial coverage, make high resolution satellite sensors attractive for many applications, including precisionThe applications of these sensors for precision agriculture are reviewed and application examples based

Keywords： high resolution satellite sensor multispectral imagery precision agriculture spatial resolution temporal

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract:

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Given the rapid development in precision medicine, tremendous efforts have been devoted to discoveringcell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precisionThe future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed

Keywords： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract:

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosisThey could also provide the ideal scheme to personalize treatment in precision medicine.

Keywords： liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine

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Special issue: Ultra-precision machining

Zhuangde JIANG,Dongming GUO

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1, Pages 1-2 doi: 10.1007/s11465-017-0445-y

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Development and application prospects of piezoelectric precision driving technology

ZHAO Chunsheng, ZHANG Jiantao, ZHANG Jianhui, JIN Jiamei

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2, Pages 119-132 doi: 10.1007/s11465-008-0034-1

Abstract: science and technology, microelectronics manufacturing, photonics technology, space technology, ultra-precisionmachining, micro-robotics, biomedical engineering and other fields urgently need the support of modern precisionModern precision driving technology can be generally divided into two parts: electromagnetic and non-electromagneticThis paper presents the development of piezoelectric precision driving technology at home and abroadmanipulation and assembly technology; 4) biomedical engineering; 5) aerospace technology; and 6) ultra-precision

Keywords： Electromagnetic ultra-precision processing technology piezoelectric cumbrous

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Research progress on ultra-precision machining technologies for soft-brittle crystal materials

Hang GAO,Xu WANG,Dongming GUO,Yuchuan CHEN

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1, Pages 77-88 doi: 10.1007/s11465-017-0411-8

Abstract:

Soft-brittle crystal materials are widely used in many fields, especially optics and microelectronics. However, these materials are difficult to machine through traditional machining methods because of their brittle, soft, and anisotropic nature. In this article, the characteristics and machining difficulties of soft-brittle and crystals are presented. Moreover, the latest research progress of novel machining technologies and their applications for soft-brittle crystals are introduced by using some representative materials (e.g., potassium dihydrogen phosphate (KDP), cadmium zinc telluride (CZT)) as examples. This article reviews the research progress of soft-brittle crystals processing.

Keywords： brittle soft functional crystal ultra-precision machining

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A hybrid deep learning model for robust prediction of the dimensional accuracy in precision milling of

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-022-0688-0

Abstract: In this study, we develop a predictive model of the dimensional accuracy for precision milling of thin-walledcomponent—squares, slots, and holes—into various categories based on their dimensional errors (i.e., “high precision

Keywords： precision milling dimensional accuracy cutting force convolutional neural networks coherent noise